Starting out with uBlock origin
My first try was to go with uBlock origin since I already had the plugin installed, and it works, but it has one big minus, and that is that (at least from what I found) can only block a site, or allow everything from it, so you are either all out or all in. It does work though.
Moving over to noscript
I've been very happy with how nice and fast the internet actually works when you don't have scripts running for each and every site, also the resource usage for my firefox has gone down quite a bit, the downside of unblocking a site now and then to get it to work is very much worth it. I'd say try it out, you might be surprised about how nice the internet is without scripting everywhere.